Болезнь Меньера начнут лечить инъекциями стероидов в барабанную перепонку
26 декабря 2016
Фото: www.istockphoto.com/SIphotography
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№155, декабрь 2016 Врач
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Болезнь Меньера начнут лечить инъекциями стероидов в барабанную перепонку
У пациентов, страдающих болезнью Меньера, возникает шум в ушах, головокружение и другие неприятные симптомы. Приступы головокружения могут продолжаться от нескольких минут до 24 часов. Группа ученых из Имперского колледжа Лондона (Imperial College London) выяснила, что инъекции стероидов в барабанную перепонку пациентов, страдающих болезнью Меньера, так же эффективны, как и инъекции гентамицина, которые считаются «золотым стандартом» терапии этого заболевания.
Болезнь Меньера – заболевание внутреннего уха, вызывающее увеличение количества жидкости (эндолимфы) в его полости. В результате болезни жидкость давит на клетки, регулирующие ориентацию тела в пространстве и сохранение равновесия.
Введение гентамицина позволяет избавить пациентов от приступов головокружения за счет разрушения клеток нейросенсорного эпителия, однако способно вызвать постоянную потерю слуха — это происходит у каждого пятого пациента. Инъекции метилпреднизолона не обладали таким побочным эффектом.
Результаты исследования были опубликованы в журнале Lancet в ноябре 2016 года. Ученые наблюдали 60 пациентов с болезнью Меньера: одна половина получала стероиды, а другая — гентамицин. Все участники испытывали в среднем один приступ головокружения в неделю. Курс обычно состоит из четырех инъекций — по одной инъекции в неделю. Через два года после начала лечения приступы головокружения стали возникать на 90 % реже у всех пациентов. Те, кому вводили стероиды, лучше слышали, чем те, кому делали укол гентамицина. Других серьезных побочных эффектов лечения обнаружено не было.
Авторы исследования теперь рекомендуют пациентам сначала проходить терапию стероидами.
Источники:
medicalnewstoday.comthelancet.com
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