Исследование: гидроксихлорохин не влияет на риск заражения коронавирусом
19 августа 2020
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№199, август 2020
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Исследование: гидроксихлорохин не влияет на риск заражения коронавирусом
Применение противомалярийного препарата гидроксихлорохин не влияет на развитие коронавирусной инфекции COVID-19 в течение четырех дней после заражения. К такому выводу пришли ученые из Университета Миннесоты в исследовании, опубликованном в журнале New England Journal of Medicine.
Напомним, что в начале года гидроксихлорохин считался одним из препаратов, способных бороться с коронавирусом. Однако в мае Всемирная организация здравоохранения призвала отказаться от дальнейших исследований применения этого ЛС у пациентов с COVID-19 из‑за кардиотоксичности, которая способна приводить к жизнеугрожающим нарушениям ритма сердца у госпитализированных пациентов.
Новая научная работа ставит под сомнение эффективность препарата в профилактике коронавирусной инфекции.
В исследовании принял участие 821 человек, имевший контакты с людьми, зараженными коронавирусом. Участники были разделены на две группы по 414 и 407 человек. Первая принимала гидроксихлорохин 800 мг однократно, затем 600 миллиграммов в течение шести-восьми часов, а после этого — по 600 миллиграммов ежедневно на протяжении четырех дней. Вторая группа получала плацебо. Препараты доставлялись на дом, а мониторинг состояний проводился дистанционно.
За время наблюдений диагноз COVID-19 был подтвержден у 107 человек — у 49 и первой группы и у 58 из второй (11,8 % и 14,3 % от общего количества участников). Такая абсолютная разница не является статистически значимой. Из этого ученые делают вывод, что гидроксихлорохин не оказывает какого‑либо заметного влияния на риск развития коронавируса.
Ранее правительство России исключило гидроксихлорохин из перечня препаратов для лечения коронавируса, поставки и оборот которых регулируются государством.
Катрен Стиль
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