Катрен Стиль
Комбинации статинов с рядом сердечно-сосудистых препаратов могут быть опасны
Статины обычно прописывают людям, входящим в группу высокого риска развития сердечно-сосудистых заболеваний. Нередко пациенты принимают статины в комбинации с другими сердечно-сосудистыми препаратами.
Специалисты из Американской ассоциации сердечно-сосудистых заболеваний (American Heart Association) предупреждают, что статины могут взаимодействовать с этими лекарствами, влияя на их эффективность. Эксперты ассоциации опубликовали список таких препаратов. Среди них фибраты, обладающие гиполипидемическим действием, блокаторы кальциевых каналов, антикоагулянты, антиаритмики и лекарства, применяющиеся для лечения сердечной недостаточности.
Чаще всего данные препараты увеличивают уровень статинов в крови, что повышает вероятность развития побочных действий: возможны мышечные боли, мышечная слабость, а также может развиться острый некроз скелетных мышц.
Барбра Уиггинс (Barbara Wiggins) из Медицинского университета Северной Каролины (Medical University of South Carolina) подчеркнула, что комбинация статинов с антикоагулянтом варфарином увеличивает риск внутреннего кровотечения.
Большинство сочетаний не снижает эффективности статинов, но некоторых комбинаций стоит избегать. Так, например, не нужно назначать статины одновременно с фибратами, в частности с гемфиброзилом.
Авторы подчеркивают важность и необходимость сердечно-сосудистых препаратов, но отмечают, что и врачи, и пациенты должны знать о возможной опасности, связанной с одновременным приемом лекарств. Пациенты должны сообщать врачам о побочных эффектах, а врачи — принимать во внимание эти жалобы и назначать иные препараты.
Материал опубликован на сайте American Heart Association в октябре 2016 года.
Источники:
webmd.comnews.heart.org
22 ноября 2016
Фото: www.istockphoto.com/Julia_Sudnitskaya
Выпуск: №154, ноябрь 2016 Врач15418 просмотров
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