Катрен Стиль
Новый тест поможет обнаружить рак шейки матки
Исследовательская группа из Медицинской школы при Университете Джонса Хопкинса (Johns Hopkins Medicine, США) предложила новый тест для диагностики рака шейки матки. Исследователи во главе с Рафаэлем Геррейро-Престоном (Rafael Guerrero-Preston) утверждают, что тест на основе анализа мочи позволяет поставить диагноз с высокой точностью.
Новый анализ способен выявлять наличие умеренного предракового состояния — цервикальной интраэпителиальной неоплазии, а также обнаружить уже присутствующие в организме опухолевые клетки. Кроме того, тест может определить наличие папилломавируса человека.
Методика состоит в измерении профиля метилирования трех генов, ассоциированных с заболеванием: FKBP6, INTS1 и ZNF516. Авторы протестировали его эффективность на 214 образцах, взятых у женщин в возрасте от 18 до 86 лет, проходивших Pap-тест (ПАП-тест), распространенный в США и Европе цитологический анализ, выявляющий раковые и предраковые клетки во влагалище и шейке матки. Правильный диагноз удалось поставить с точностью 90 %, а в 89 % случаев ученые верно определили, что у женщин отсутствует какая‑либо патология.
В дальнейшем тест был усовершенствован и стал способен распознавать присутствие гена папилломавируса человека HPV16‑L1. Этот вирус с высокой вероятностью провоцирует возникновение рака шейки матки. Чувствительность нового теста составила 91 %, а его специфичность — 61 %. Результаты были опубликованы в ноябре 2016 года в журнале Cancer Prevention Research.
Проведение такого теста позволяет быстро получить ответ, необходима ли срочная биопсия или же врачи могут придерживаться выжидательной позиции.
Источники:
cancerpreventionresearch.aacrjournals.orgnews-medical.net
11 декабря 2016
Фото: www.istockphoto.com/fstop123
Выпуск: №155, декабрь 2016 Врач1454 просмотров
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1454 просмотров
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