Популярные антимикробные препараты повышают риск опасного для жизни расслоения аорты
16 марта 2018
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№170, март 2018
3335 просмотров
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Популярные антимикробные препараты повышают риск опасного для жизни расслоения аорты
Ученые из Каролинского университета в Швеции изучили влияние на организм противомикробных препаратов из группы фторхинолонов и пришли к выводу, что они на 66 % увеличивают риск аневризмы и расслоения аорты. Статью с описанием исследования опубликовали 8 марта в журнале BMJ.
Ученые изучили записи более 360 тысяч пациентов, принимавших фторхинолоны (в 78 % случаев это был ципрофлоксацин), и такого же количества больных, которым были прописаны другие группы антибиотиков (в частности амоксициллин).
Обнаружилось, что через 60 дней после начала лечения у пациентов, получавших фторхинолоны, на 66 % повышался риск аневризмы или расслоения аорты. Частота таких случаев составила 1,2 на 1000 человек против 0,7 на 1000 больных, принимавших другие антибиотики. Таким образом, принимавшие фторхинолоны пациенты получали осложнения в 1,7 раза чаще. Отметим, что расслоение аорты в тяжелой форме приводит к смертельно опасной потере крови.
Исследователи видят возможную причину такого эффекта в том, что фторхинолоны могут активировать матриксные металлопротеиназы, которые разрушают целостность сосудистой стенки. Однако, для того чтобы более точно описать механизм разрушения сосудов, потребуются дополнительные исследования.
Фторхинолоны — антимикробные препараты, синтезированные в 1960‑х годах и часто применяющиеся в качестве антибактериальных средств широкого спектра. В настоящее время аневризма или расслоение аорты не указываются как побочное действие их применения.
К фторхинолонам относятся такие вещества, как:
ципрофлоксацин;
пефлоксацин;
норфлоксацин;
ломефлоксацин;
спарфлоксацин;
левофлоксацин;
моксифлоксацин;
гемифлоксацин;
гатифлоксацин.
Катрен Стиль
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