Катрен Стиль
Прием ингибиторов протонной помпы связан с повышенным риском инсульта
Ингибиторы протонной помпы (ИПП) блокируют секрецию соляной кислоты париетальными клетками желудка и широко применяются в терапии язвенной болезни и изжоги. Использовать их следует с осторожностью, так как прием ИПП может увеличить риск развития ишемического инсульта.
Томас Сехестед (Thomas Sehested) и его коллеги из Датского фонда исследований сердца (Danish Heart Foundation) провели исследование, в котором приняло участие почти 245 тысяч жителей Дании, средний возраст составил 57 лет. За участниками исследования наблюдали в среднем в течение 6 лет — за это время ишемический инсульт возник почти у 9,5 тысяч человек.
Участники принимали один из четырех ИПП: омепразол, пантопразол, лансопразол и эзомепразол. Прием ИПП увеличивал риск развития ишемического инсульта (85 % всех случаев инсульта) на 21 %. Самым опасным оказался пантопразол, прием высоких доз которого повышал вероятность развития ишемического инсульта на 94 %. Низкие дозы всех препаратов на риск возникновения инсульта практически не влияли. Полученные результаты были представлены на Научной сессии Американской кардиологической ассоциации (American Heart Association»s Scientific Sessions) в ноябре 2016 года.
Ученые пока не могут утверждать, что именно прием ингибиторов протонной помпы провоцирует развитие инсульта. Они отмечают, что ранее употребление этих препаратов считалось безопасным, так как серьезные побочные эффекты обнаружены не были.
Источники:
medicalnewstoday.comprofessional.heart.org
19 декабря 2016
Фото: www.istockphoto.com/eranicle
Выпуск: №155, декабрь 2016 Врач2144 просмотров
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