Ученые: действие аспирина зависит от веса пациента
20 июля 2018
Выпуск:
№174, июль 2018
1677 просмотров
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Ученые: действие аспирина зависит от веса пациента
Ученые из Центра по предотвращению инсульта и деменции (Centre for Prevention of Stroke and Dementia) в английском Оксфорде провели исследование и установили, что эффективность дозировки аспирина при профилактике сердечно-сосудистых заболеваний во многом зависит от веса пациента. Статья об этом опубликована 12 июля в журнале Lancet.
Для исследования были отобраны результаты 10 разных испытаний эффективности аспирина при профилактике сердечно-сосудистых заболеваний. Ученые старались выявить взаимосвязь действия аспирина и веса пациентов. Всего ученые проанализировали данные свыше 117 тысяч человек, вес которых варьировался от 60 до 81 килограмма.
В результате анализа исследователи выяснили, что низкие дозы аспирина (75–100 мг в сутки) снижали риск сердечно-сосудистых осложнений только у людей с массой тела до 70 кг. У пациентов с большим весом, соответственно, снижение риска вреда здоровью начиналось при более высоких дозировках — от 325 мг в сутки.
Кроме этого, исследование показало, что для пациентов весом более 70 кг небольшие дозы препарата не только практически не имеют эффекта, но и способствуют повышению риска проблем с сердцем и сосудами в среднем на 33 %.
Таким образом, ученые из Оксфорда считают, что оптимальную дозировку аспирина следует подбирать для пациента индивидуально, чтобы лечение дало максимум результата и имело минимум побочных эффектов. Кроме этого, описанное исследование может быть использовано при подготовке будущих клинических испытаний аспирина, поскольку нынешние рандомизированные исследования препарата чаще всего основываются на определенной дозировке, исключая большинство других факторов, которые могут повлиять на результаты.
Ранее канадские медики продемонстрировали возможность использовать аспирин как бюджетную замену дорогостоящему антикоагулянту — ривароксабану.
Катрен Стиль
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