Катрен Стиль15 ноября 2018
Выпуск: №178, ноябрь 20181601 просмотров
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Ученые предложили вводить препараты в глаза при помощи растворимых иголок
Исследователи из Наньянского технологического университета в Сингапуре представили новый способ введения лекарственных препаратов внутрь глаза с помощью микроскопических проникающих резервуаров, растворяющихся вместе с ЛС. Статья с подробным описанием новой технологии опубликована в журнале Nature.
Исследователи предложили использовать для доставки лекарств технологию микроигл с действующим веществом, которая уже применяется в различных инновационных трансдермальных системах. Например, в июне этого года в США завершились клинические испытания пластыря с микроиглами, содержащими вакцину от гриппа.
Изобретение ученых из Сингапура по принципу действия похоже на этот пластырь, и представляет собой миниатюрную пластину, на поверхности которой находятся микроскопические резервуары, выполненные в форме иголок. Пластину следует слегка прижать к глазу так, чтобы иголки вошли в защитную поверхность ткани роговицы. После этого иголки отделяются от пластины и растворяются, выпуская необходимый препарат.
Первые испытания были проведены в виде лечения неоваскуляризации роговицы у мышей. По наблюдениям ученых, новый метод позволил вылечить 90 % неоваскулярной области у грызунов, а также не вызвал никаких повреждений глаза или признаков боли. В ближайшем времени ученые планируют начать клинические исследования новой лекарственной формы с участием людей.
Ранее в Китае были разработаны контактные линзы с лекарственным препаратом, меняющие свой цвет при выделении действующего вещества.
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