Катрен СтильУченые: содержащееся в винограде вещество может защитить от рака легких
Группа исследователей из Женевского университета (Universite de Geneve, Швейцария) выяснила, что природное вещество ресвератрол, получаемое из кожуры винограда, может использоваться в профилактике рака легких. Об этом 3 октября пишет портал «EruekAlert!».
Ресвератрол — фитоалексин, выделяемый некоторыми растениями в качестве защитной реакции против паразитов, таких как бактерии или грибы. Его противоопухолевые свойства были открыты еще в конце 90‑х годов. Однако, ранее ресвератрол не показывал значительных результатов в терапии рака легких. Во многом это связано с его низкой биодоступностью — до легких доходило слишком малое количество вещества, большая же его часть быстро усваивалась организмом.
Для изучения влияния ресвератрола на рак легких ученые использовали не оральный, а назальный способ введения вещества. Таким образом напрямую в легкие попадает большее количество фитоалексина.
Пока эксперименты проводились только на лабораторных мышах. Они были разделены на четыре группы: одна часть получала карциногенные вещества, содержащиеся в сигаретах, вторая — карциногены совместно с ресвератролом, животные из третьей группы получали только ресвератрол, а четвертая группа была контрольной и не подвергалась никаким дополнительным манипуляциям.
В результате наблюдений, длившихся 26 недель, у 45 % мышей, получавших ресвератрол+карциногены, опухолей развилось меньше (и меньшего размера), чем у животных, получавших только карциногены.
Прежде чем ресвератрол можно будет использовать в профилактике рака легких, его ждут клинические испытания на людях. Но для этого, отмечают ученые, необходимо сначала найти биомаркеры, ответственные за предрасположенность к развитию опухолей.
4 октября 2018
Выпуск: №177, октябрь 20181343 просмотров
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