В Японии научились бороться с гриппом за одни сутки
21 февраля 2018
Выпуск:
№169, февраль 2018
2570 просмотров
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В Японии научились бороться с гриппом за одни сутки
Японская фармацевтическая компания Shionogi & Co разработала препарат, способный уничтожить вирус гриппа в организме в течение 24 часов. Об этом 13 февраля пишет портал ScienceAlert.
Препарат пока не имеет торгового наименования и называется балоксавир марбоксил (baloxavir marboxil). Вещество относится к классу ингибиторов эндонуклеаз. Оно блокирует активность белков эндонуклеаз, тем самым делая клетки организма более устойчивыми к вирусу и препятствуя его размножению. Схожий принцип блокирования частей клеточных РНК лежит в основе современных препаратов против ВИЧ.
Клинические исследования проводились с участием 1 436 человек с диагнозом «Грипп». Испытуемые были разделены на три группы. Первая группа принимала одну дозу в составе 40–80 мг препарата (в зависимости от веса пациента), вторая группа принимала 75 мг осельтамивира (распространенный препарат против вируса) в течение 5 дней, третья группа получала плацебо. Ислледования показали, что балоксавир марбоксил уничтожал вирус гриппа в организме в среднем за 24 часа. Подобные результаты у группы, принимавшей осельтамивир, достигались за 72 часа. У группы плацебо — за 96 часов.
Балоксавир марбоксил был одобрен для применения министерством здравоохранения Японии. В продаже препарат должен появиться в мае этого года. Планирует ли производитель поставлять новое лекарство в другие страны, неизвестно.
Катрен Стиль
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