Гормональная терапия при раке простаты может спровоцировать деменцию
27 октября 2016
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№153, октябрь 2016 Фарма
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Гормональная терапия при раке простаты может спровоцировать деменцию
Мужчины, которым назначают гормональную терапию при лечении рака предстательной железы, имеют повышенный риск развития деменции. Антиандрогенная терапия используется для снижения уровня мужских гормонов — тестостерона и дигидротестостерона, которые могут стимулировать рост опухолевых клеток. Гормональная терапия назначается в том случае, если хирургический подход или лучевая терапия оказываются неэффективны или для повышения их эффективности, или в случае рецидива.
Кевин Нид (Kevin T. Nead) и его коллеги из Перельмановской медицинской школы при Университете Пенсильвании (Perelman School of Medicine at the University of Pennsylvania) провели исследование, в котором приняло участие более 9 тысяч мужчин, проходивших лечение от рака простаты в период с 1994 по 2013 год, 1826 из них была назначена антиандрогенная терапия. Средний возраст участников исследования составлял 67 лет.
Оказалось, что у тех, кто проходил гормональную терапию, вероятность возникновения деменции в течение пяти лет после окончания курса была выше в 2 раза по сравнению с теми, кому такая терапия не назначалась (эти показатели составляли 7,9 % и 3,5 % соответственно).
Авторы исследования предполагают, что тестостерон каким‑то образом защищает клетки головного мозга, а снижение уровня этого гормона приводит к тому, что клетки повреждаются, и риск развития деменции возрастает.
Источники:
medicalnewstoday.comjamanetwork.com
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