Катрен СтильУченые предложили альтернативу опиоидным обезболивающим
Исследователи из Университетского колледжа Лондона в Англии представили назальный спрей, который может стать альтернативой современным опиоидным обезболивающим. Об этом 1 февраля пишет South China Morning Post. Полный текст статьи с результатами работы ученых был опубликован в журнале Journal of Controlled Release.
В основе действия обезболивающего лежат лей-энкефалины — эндогенные опиоидные пептиды, которые вместе с эндорфинами воздействуют на опиоидные рецепторы и смягчают восприятие болевых ощущений.
Энкефалины в настоящий момент не применяются при обезболивании, поскольку они действуют только при непосредственном введении в мозг пациента. При внутривенной инъекции или приеме таблеток они разрушаются быстрее, чем достигают мозга.
Чтобы избежать этого, ученые предложили использовать лекарственную форму назального спрея. Энкефалины были помещены в микроскопические капсулы из разлагаемого полимера. Проходя через носовые ходы, они могут достигать необходимых участков мозга пациента, не успев разложиться, тем самым смягчая боль.
Спрей был успешно протестирован на лабораторных мышах. При этом в сравнении с группой животных, принимавшей морфин, у мышей не наблюдалось симптомов возникновения зависимости от энкефалинов.
В настоящий момент ученые ищут средства для проведения I фазы клинических испытаний нового обезболивающего, чтобы определить безопасность его применения для человека.
3 февраля 2018
Выпуск: №169, февраль 20181934 просмотров
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